陈薛钗 副教授 硕士生导师
联系电话:010-67396342
E-mail:chenxuechai@bjut.edu.cn
通讯地址:威尼斯wns.8885556生命楼B303室
教育背景
2005.09-2011.06,北京理工大学,生命学院,博士
2001.09-2005.06,温州师范学院,生物与环境科学系,学士
工作经历
2021.07-至今,威尼斯wns.8885556,威尼斯wns.8885556,副教授,硕士生导师
2013.06-2021.07,威尼斯wns.8885556,生命学院,助理研究员,硕士生导师
2011.06-2013.06,威尼斯wns.8885556,生命学院,博士后
研究方向
神经退行性疾病的关键致病因子/分子机制研究
神经退行性疾病的表观遗传学研究
课程教学
本科生专业基础课《生物化学》、《生化与分子生物学实验》、《脑科学导论》
本科通识教育课程《诺贝尔奖与生命科学》
研究生课程《生物医学综合》、《生命科学实验技术》
奖项荣誉
2014年获得CLES优秀青年学者奖
2018年和2020年获得威尼斯wns.8885556优秀硕士学位论文指导教师奖
主要科研项目
2015-2017 国家自然科学基金青年基金项目(81400935)主持
2020-2022北京市自然科学基金面上项目(7202001)主持
2020-2022北京市教委项目(KM202010005022)主持
2012-2013国家博士后基金(2012M510302)主持
2012-2013北京市博士后基金(2012ZZ-02)主持
主要论文论著
[1] Xuechai Chen, Jianan Wang, Muhammad Tahir, Fangfang Zhang, Yuanyuan Ran, Zongjian Liu, Juan Wang. Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases. Cell Biosci. 2021, 11(1):147.
[2] Qianqian Xiong, Xiaotong Zheng, Jianan Wang, Zixuan Chen, Yulin Deng, Rugang Zhong, Juan Wang, Xuechai Chen*. Sal synthase induced cytotoxicity of PC12 cells through production of the dopamine metabolites salsolinol and N-methyl-salsolinol. J Integr Neurosci. 2021, March 15.
[3] Xuechai Chen*, Chunyu Yu, Minjun Guo, et al. Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death. ACS Chem Neurosci. 2019, 10(5):2355-2363.
[4] Xuechai Chen*, Chunyu Yu, Minjun Guo, Xiaotong Zheng. Determination of m6A mRNA methylation in Parkinson's disease model. J Neurochem. 2019, 105: 211.
[5] Xuechai Chen, Xiaotong Zheng, Sakhawat Ali, et al. Isolation and Sequencing of Salsolinol Synthase, an Enzyme Catalyzing Salsolinol Biosynthesis. ACS Chem Neurosci. 2018, 9(6):1388-1398.
[6] Xiaotong Zheng, Xuechai Chen*, Minjun Guo, et al. Changes in salsolinol production and salsolinol synthase activity in Parkinson's disease model. Neurosci. Lett. 2018, 673: 39-43.
[7] Minjun Guo, Xinhui Liu, Xiaotong Zheng, Yinghui Huang, Xuechai Chen*. m6A RNA Modification Determines Cell Fate by Regulating mRNA Degradation. Cell Reprogram. 2017, 19(4): 1-7.
[8] Abida Arshad #, Xuechai Chen #(co-first author), Zhenzhen Cong, Hong Qing, Yulin Deng *. TRPC1 protects dopaminergic SH-SY5Y cells from MPP+, salsolinol, and N-methyl-(R)- salsolinol induced cytotoxicity, Acta Biochim Biophys Sin, 2014, 46(1): 22-30.
[9] Xuechai Chen, Yulin Deng, Yi Lin, et al. Quantum dot-labeled aptamer bioprobes specifically targeting glioma cells. Nanotechnology, 2008, 19: 235105.
[10] 陈薛钗, 邓玉林. 分离纯化Salsolinol合成酶的方法. 2020年, 授权号:CN 107460183 B.(专利)