赵洪武 副研究员 硕士生导师
联系电话：86-10-67396211
通讯地址：北京市朝阳区平乐园100号，
威尼斯wns.8885556威尼斯wns.8885556，化学与生物系，生命楼B624研究室
电子邮箱：hwzhao@bjut.edu.cn
教育背景
1997年--2000年，北京大学，化学与分子工程学院，博士
1992年--1995年，东北师范大学，化学系，硕士
1988年--1992年，东北师范大学，化学系，本科
工作经历
2007年--现在，威尼斯wns.8885556，副研究员
2006年--2007年，开拓者制药公司（美国Eli Lilly)，研发总监
2004年--2006年，美国普渡大学，药学院，博士后
2001年--2004年，美国弗吉尼亚理工大学，化学系，博士后
2000年--2001年，香港大学，化学系，博士后
1995年--1997年，大连理工大学，石油化工学院，讲师
研究方向
1. 靶向性抗肿瘤药物的设计与合成
2. 手性螺（稠）杂环类药性分子骨架的设计与合成
3. 不对称有机催化和金属催化有机合成方法学的研究
4. 手性识别的研究
课程教学
有机化学（主讲）、生物材料（主讲）、药物合成（主讲/双语）、药物化学（双语/主讲）、生物医学工程概论、药物合成技术
奖项荣誉
1. 威尼斯wns.8885556优秀硕士学位论文指导教师（11次）
2. 威尼斯wns.8885556绩效考核优秀奖（4次）
3. 威尼斯wns.8885556“双带头人”教师党支部书记示范工作室（2019年）
4. 生命科学与生物工程学院（原）优秀共产党员（2017年）
5. 北京市人才强教深化计划中青年骨干人才（2010年）
主要科研项目
作为项目负责人，主持了国家科技重大专项1项、北京市自然科学基金3项、北京市教委项目2项、北京市人才强教深化计划中青年骨干人才项目1项、企业委托项目2项、校级项目2项。作为研究骨干，参与了国家重点基础研究发展计划2项、国家科技重大专项2项、北京市教委项目1项。
1. 靶向FBPase的抗糖尿病新药研究病，国家重大专项，主持，2018/01-2020/12
2. 新型手性螺环巴比妥的设计、合成和抗肿瘤活性评价药研究，北京市自然科学基金，主持，2017/01-2019/12
3. 新型双功能小分子催化剂的设计、合成和不对称催化反应的研究, 北京市自然科学基金，主持，2012/01-2014/12
4. 新型桥连联苯化合物的设计、合成与抗肿瘤活性研究，北京市自然科学基金，主持，2010/01-2012/12
5. 新型(-)-Rhazinilam桥连联芳基化合物的设计、立体选择性合成和构效关系研究，北京市人才强教计划，主持，2010/01-2013/12
6. 新型秋水仙碱B环类似物的设计、合成和构效关系研究，北京市教委项目，主持，2009/01-2011/12
7. 芳基二氢吡啶酮化合物的合成，企事业委托项目，主持，2010/01-2011/12
主要论文论著
在J. Am. Che. Soc., Org. Lett., Chem. Commun.，Adv. Synth. & Catal., J. Org. Chem.等 SCI收录的国际著名学术刊物上发表科研论文50余篇；申请国家发明专利10余项。
一、 代表性SCI论文
1. Xiao-Zu Fan, Hui-Hui Wu, Zhe Tang, Heng Zhang, Lu-Yu Cai, Xiao-Fan Bi, Hong-Wu Zhao,* Formal [3+2] Cycloaddition Between in situ Formed 1,4-Benzodiazepin-2-One-Based Azomethine Ylides with Azodicarboxylic Acid Derivatives: Diastereoselective Synthesis of Spiro-1,4-Benzodiazepin-2-Ones, Adv. Synth.& Catal., 2021 (Accepted )
2. Hui-Hui Wu, Xiao-Zu Fan, Zhe Tang, Heng Zhang, Lu-Yu Cai, Xiao-Fan Bi, Hong-Wu Zhao,* Palladium/Ligand Complex Catalyzed Formal [5 + 6] Cycloaddition of Vinylethylene Carbonates with Isatoic Anhydrides for Synthesis of Medium-Sized N,O-Containing Heterocycles, Org. Lett., 2021 (Under revision)
3. H. W. Zhao,* L. R. Wang,W. Q. Ding, et al. Formal [5+3] Cycloaddition between Isatin-Based α-(Trifluoromethyl)imine Ylides and Vinyloxiranes: Diastereoselective Access to Medium-Heterocycle-Fused Spirooxindoles, Synlett, 2021, 32(01), 57-62.
4. Jia-Ming Guo, Xiao-Zu Fan, Hui-Hui Wu, Zhe Tang, Xiao-Fan Bi, Heng Zhang, Lu-Yu Cai, Hong-Wu Zhao,* and Qi-Di Zhong. Asymmetric Synthesis of Spiropyrazolones via Chiral Pd(0)/Ligand Complex-Catalyzed Formal [4+2] Cycloaddition of Vinyl Benzoxazinanones with Alkylidene Pyrazolones, J. Org. Chem. 2020 (DOI:10.1021/acs.joc.0c02524)
5. H. W. Zhao,* W. Q. Ding, L. R. Wang, et al Formal [5+2] Cycloaddition of Vinyloxiranes with Oxazol-5-(4H)-ones: A Facile Approach for Construction of Seven-Membered Lactones, Eur. J. Org. Chem., 2020, 2020(34), 5557-5562,
6. H. W. Zhao,* J. M. Guo, L. R. Wang, et al.Diastereoselective formal [3+3] cycloaddition of isatin-based alpha-(trifluoromethyl)imines with N,N '-dialkyloxyureas, Org. Chem. Front., 2019, 6, 3891-3895,
7. H. W. Zhao,* W. Q. Ding, J. M. Guo, et al. Formal [4+2] Cycloaddition of Vinyl Benzoxazinones with Oxazol-5-(4H)-ones for Diastereoselective Construction of 3,4-Disubstituted Dihydro-2(1H)-Quinolinones, Adv. Synth.& Catal., 2019, 361(17),4111-4116,
8. H. W. Zhao,* L. R. Wang, J. M. Guo, et al. Formal [5+3] Cycloaddition of Vinylethylene Carbonates with Isatin-Based alpha-(Trifluoromethyl)imines for Diastereoselective Synthesis of Medium-Heterocycle-Fused Spirooxindoles, Adv. Synth.& Catal., 2019, 361(20), 4761-4771,
9. Hong-Wu Zhao,* Juan Du, Jia-Ming Guo, Ning-Ning Feng, Li-Ru Wang,Wan-Qiu Ding and Xiu-Qing Song，Formal [5+2] cycloaddition of vinylethylene carbonates to oxazol-5-(4H)-ones for the synthesis of 3,4-dihydrooxepin-2(7H)-ones, Chem. Commun., 2018, 54, 9178–9181,
10. Hong-Wu Zhao,* Ning-Ning Feng, Jia-Ming Guo, Juan Du, Wan-Qiu Ding, Li-Ru Wang,and Xiu-Qing Song Diastereoselective and Enantioselective Synthesis of Barbiturate-Fused Spirotetrahydroquinolines via Chiral Palladium(0)/Ligand Complex Catalyzed [4 + 2] Cycloaddition of Vinyl Benzoxazinanones with Barbiturate-Based Olefins，J. Org. Chem.， 2018, 83, 9291-9299,
11. Hong-Wu Zhao,* Yue-Yang Liu, Yu-Di Zhao,Ning-Ning Feng,Juan Du, Xiu-Qing Song, Hai-Liang Pang, Xiao-Qin Chen, Base-catalyzed [3+2] Cycloaddition of Diazooxindoles with Oxazol-5-(4H)-ones for Synthesis of Novel 3-(1H-1,2,4-triazol-1-yl)indolin-2-ones, Eur. J. Org. Chem., 2018，2017，341-346,
12. Hong-Wu Zhao,* Yu-Di Zhao, Yue-Yang Liu, Li-Jiao Zhao,Xiu-Qing Song, Xiao-Qin Chen, Hai-Liang Pang, Juan Du and Ning-Ning Feng, 1,3-Dipolar [3 + 3] cycloaddition of ahalohydroxamate-based azaoxyallyl cations with hydrazonoyl chloride-derived nitrile imines, RSC Adv., 2017, 7, 55106–55109,
13. Hong-Wu Zhao,* Xiao-Qin Chen, Yu-Di Zhao, Yue-Yang Liu, Hai-Liang Pang, Xiu-Qing Song, TingTian, Bo Li, Zhao Yang, Juan Du, Ning-Ning Feng, [3+2] Cycloaddition Between3-Isothiocyanato Oxindoles and Nitroso Compounds, Eur. J. Org. Chem., 2017，2017，3139-3144,
14. Hong-Wu Zhao,* Yu-Di Zhao, Yue-Yang Liu, Juan Du, Hai-Liang Pang, Xiao-Qin Chen, Xiu-QingSong, Ning-Ning Feng, Base-promoted [3+2] Cycloaddition of in situ formedAzaoxyallyl Cations with Isothiocyanides, Eur.J. Org. Chem., 2017，2017, 3466–3472,
15. Hong-Wu Zhao,* Hai-Liang Pang, Yu-Di Zhao, Yue-Yang Liu, Li-Jiao Zhao, Xiao-Qin Chen, Xiu-Qing Song, Ning-Ning Feng and Juan Du， Construction of 2,3,4,5-tetrahydro-1,2,4-triazines via [4 + 2] cycloaddition of α-halogeno hydrazones to imines，RSC Adv., 2017,7, 9264-9271,
16. Hong-Wu Zhao,* Yu-Di Zhao,Yue-Yang Liu, Li-Jiao Zhao,* Ning-NingFeng, Hai-Liang Pang, Xiao-Qin Chen, Xiu-Qing Song, Juan Du， A facile access to novel 1,2,4-oxadiazinan-5-ones via [3+3] cycloaddition of in situ generated azaoxyallyl cations with nitrones，RSC Adv., 2017，7, 12916-12922,
17. Hong-Wu Zhao,* Yue-Yang Liu, Yu-Di Zhao, Hai-Liang Pang, Xiao-Qin Chen, Xiu-Qing Song, Ting Tian, Bo Li, Zhao Yang, Juan Du, Ning-Ning Feng， [3 + 2] Cycloaddition of Oxazol-5-(4H)-ones with Nitrones for Diastereoselective Synthesis of Isoxazolidin-5-ones, Org. Lett.,2017，19，26-29,
18. Hong-Wu Zhao,* Hai-Liang Pang, Ting Tian, Bo Li, Xiao-Qin Chen, Xiu-Qing Song, Wei Meng, Zhao Yang, Yue-Yang Liu, Yu-Di Zhao, Construction of 2,3,4,7-tetrahydro-1,2,4,5-oxatriazepine via [4+3] cycloaddition of α-halogenohydrazones with nitrones, Adv. Synth.& Catal. 2016, 358,1826–1832,
19. Hong-Wu Zhao,* Bo Li, Hai-Liang Pang, Ting Tian,Xiao-Qin Chen, Xiu-Qing Song, Wei Meng, Zhao Yang, Yu-Di Zhao, Yue-Yang Liu， Diastereoselective1,3-dipolar cycloadditions of N, N’-cyclic azomethine imines with iminooxindoles foraccess to oxindole-spiro-N,N-bicyclic heterocycles, Org. Lett. 2016，18， 848-851,
20. Hong-Wu Zhao,* Hai-Liang Pang, Bo Li, Ting Tian, Xiao-Qin Chen, Xiu-Qing Song, Wei Meng, Zhao Yang, Yue-Yang Liu, Yu-Di Zhao, Direct Access to Non-Aromatic 1,2,3,6-Tetrahydro -1,2,3,4-Tetrazines via [4+2] Cycloaddition of α-HalogenoHydrazones with AzodicarboxylicAcid Derivatives,RSC Adv.2016,6, 25562-25567,
21. Hong-Wu Zhao,* Ting Tian, Hai-Liang Pang, Bo Li, Zhao Yang, Wei Meng, Xiu-Qing Song,Xiao-Qin Chen, Organocatalytic [3+2] Cycloaddition of Barbiturate-Based Olefinswith 3-Isothiocyanato Oxindoles: Highly Diastereoselective and Enantioselective Synthesis of Dispirobarbiturates，Adv. Synth. & Catal. 2016, 358, 2619-2630,
22. Hong-Wu Zhao,* Bo Li, Ting Tian, Xiu-Qing Song, Hai-Liang Pang, Xiao-Qin Chen, Zhao Yang, Wei Meng, Facile construction of novel imidazolidine-spirooxindoles via diastereoselectivecycloaddition of N-acylhydrazine-derived imines with 3-isothiocyanato oxindoles, RSC Adv. 2016,6, 27690-27695,
23. Hong-Wu Zhao,* Xiao-Qin Chen,Hai-Liang Pang,Ting Tian,Bo Li,Xiu-Qing Song,Wei Meng,Zhao Yang,Yu-Di Zhao,Yue-Yang Liu, Diastereoselective synthesis of highly functionalized polycyclic benzosultams via tandem cyclisationsof cyclic N-sulfonylimineswith in situ generatedHuisgen 1,4-dipoles, RSC Adv.2016，6, 61732-61739,
24. Zhao, H.-W.;* Tian, T.; Li, B.; Yang, Z.; Pang, H.-L.; Meng, W.; Song, X.-Q.; Chen, X.-Q., Diastereoselective Synthesis of Dispirobarbiturates through Et3N-Catalyzed [3 + 2] Cycloaddition of Barbiturate-Based Olefins with 3-Isothiocyanato Oxindoles. J. Org. Chem. 2015, 80, 10380-10385,
25. Zhao, H.-W.;* Chen, X.-Q.; Yang, Z.; Tian, T.; Li, B.; Meng, W.; Song, X.-Q.; Pang, H.-L., Highly diastereoselective synthesis of imidazolidine-dispirooxindoles via three-component [3 + 2] cycloadditions of isatins, 2-(aminomethyl)pyridine and isatin-based imines. RSC Adv. 2015, 5, 103116-103122,
26. Zhao, H.-W.;* Yang, Z.; Meng, W.; Tian, T.; Li, B.; Song, X.-Q.; Chen, X.-Q.; Pang, H.-L., Diastereo- and Enantioselective Synthesis of Chiral Pyrrolidine-Fused Spirooxindoles via Organocatalytic [3+2] 1,3-Dipolar Cycloaddition of AzomethineYlides with Maleimides. Adv. Synth. & Catal. 2015,357, 2492-2502,
27. Zhao, H.-W.;* Li, B.; Tian, T.; Meng, W.; Yang, Z.; Song, X.-Q.; Chen, X.-Q.; Pang, H.-L., Highly Enantioselective Synthesis of Chiral Pyranonaphthoquinone-Fused Spirooxindoles through Organocatalytic Three-Component Cascade Reactions. Eur. J. Org. Chem. 2015,2015, 3320-3326.
28. Paul R. Carlier,* Hongwu Zhao, Stephanie L. MacQuarrie-Hunter, Joseph C. DeGuzman, and Danny C. Hsu,Enantioselective Synthesis of Diversely Substituted Quaternary 1,4-Benzodiazepin-2-ones and 1,4-Benzodiazepine-2,5-diones. J. Am. Soc. Chem. 2006,128, 15215-15220.
29. Paul R. Carlier,* Hongwu Zhao, Joe DeGuzman, and Polo C.-H. Lam.Enantioselective Synthesis of “Quaternary” 1,4-Benzodiazepin-2-one Scaffolds via Memory of Chirality. J. Am. Chem. Soc. 2003,125, 11482-11483.
30. Hongwu Zhao and Wenting Hua.* Synthesis and Characterization of Pyridine-Based Polyamido-Polyester Optically Active Macrocycles and Enantiomeric Recognition for d- and l-Amino Acid Methyl Ester Hydrochloride. J. Org. Chem. 2000, 65, 2933-2938.
二、 代表性国家发明专利
1. 一种3，4-二氢氧基-2（7H）-酮及制备方法, 专利号：201810449534.0，第一发明人.
2. 一种八元氮氧杂环螺吲哚酮化合物及制备方法，专利号：201811028971.1，第一发明人.
3. 一种手性3,4-二氢-2(1H)-喹啉酮类化合物及制备方法，专利号: 201811574684.0，第一发明人.
4. 一种手性巴比妥螺四氢喹啉类化合物及制备方法, 专利号：201810449570.7， 第一发明人.
5. 一种手性1,4-苯并二氮-2-酮螺杂环化合物及制备方法, 专利号：202011442438.7，第一发明人
6. , 一种氮杂中环内酯化合物及制备方法，专利号：202011441268.0，第一发明人
