闫红 博士生导师
联系电话：
E-mail：bjut.edu.cn@bjut.edu.cn
通讯地址：威尼斯wns.8885556威尼斯wns.8885556生命科学与化学学院
教育背景
博士学位，有机合成化学, 1994, 8, 北京理工大学
硕士学位，有机化学，1989,3 北京理工大学
学士学位，有机化学工程，1984, 7 北京理工大学
工作经历
1984,7---1986,8，辽宁省庆阳化工厂师。
1994,8---现在，威尼斯wns.8885556。
研究方向
多面体烷类化合物的合成和药理活性筛选，新合成方法在药物合成中的应用，多糖类天然产物的提取分离和改性的研究。
课程教学
有机化学，高等有机化学，药物合成化学，药物合成与新技术，生物技术等。
奖项荣誉
北京市科技进步三等奖三项，获北京市优秀青年骨干教师荣誉称号，并入选北京市科技新星计划。
主要科研项目
目前工作的重点是以药物合成和天然产物有效成分的提取、分离、改性等为基础而进行的抗病毒、抗肿瘤等药物，以及创新药物的研发等。主持了国家十一五和十二五科技重大专项的关于艾滋病和病毒性肝炎等重大传染病防治研究项目，主持了国家自然科学基金和北京市自然科学基金重点和面上等科研项目，申报国家发明专利二十余项，获授权二十余项，在国外和国内核心刊物上发表论文百余篇。
主要论文论著
1. Peng Li, Shijie Wang, Nana Tian, Hong Yan*, Juan Wang* and Xiuqing Song, Studies on Chemoselective Synthesis of 1,4- and 1,2-Dihydropyridine Derivatives by Hantzsch-Like Reaction: A Combined Experimental and DFT Study, Organic & Biomolecular Chemistry, 17: 3882-3892, 2021
2. Shijie Wang, Huiqin Wang, Nana Tian, Xiaokun Zhang, Hong Yan*, Insights for Diastereoselectivity in Synthesis of 2,3-dihydropyrroles by Photochemical Ring Contraction of 1,4-dihydropyridines, Tetrahedron Letters 65 (2021) 152797
3. Xiaokun Zhang, Effects of photophysical properties of 1,4-cyclohexadiene derivatives on their [2+2] photocycloaddition reactivities: experimental and theoretical studies, Journal of Photochemistry & Photobiology, A: Chemistry, 416 (2021) 113336,1-8
4. Wenzhi Ma, Yanyu Wang, Dongchen Chu, Hong Yan*, 4D-QSAR and MIA-QSAR study on the Bruton's tyrosine kinase (Btk) inhibitors, Journal of Molecular Graphics and Modelling 92 (2019) 357-362.
5. Shengquan Hu, Zhichang Zhao, Hong Yan. Discovery and optimization of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one derivatives as mTORC1/mTORC2 dual inhibitors. Bioorganic Chemistry, 2019, 103232.
6. Shengquan Hu, Wuji Sun, Yeming Wang, Hong Yan*, Design, synthesis, and anticancer activities of halogenated Phenstatin analogues as microtubule destabilizing agent, Medicinal Chemistry Research, 2019, 28(4), 465-472.
7. Fan Q, Duan X, Yan H*. Solid state [2+2] photocycloaddition for constructing dimers of N,N’-diacyl-1,4-dihydropyrazines based on thiourea-induced assembly[J]. Cryst Eng Comm, 2018, 20:1151-1157.
8. Qiangwen Fan, Peng Li, Hong Yan*, Photophysical properties of 2,6-unsubstituented 1,4-dihydropyridines: Experimental and theoretical studies, Journal of Photochemistry and Photobiology A: Chemistry, 2018, 358, 51-60.
9. Tan H, Zhao Z, Yan H*. Highly regioselective photodimerization of 1,4-dihydropyridines: An efficient synthesis of novel 3,6-diazatetraasteranes[J]. Tetrahedron, 2018, 74(6):529-534.
10. Wuji Sun, Shengquan Hu, Shubiao Fang, Hong Yan*, Design, synthesis and biological evaluation of pyrimidine-based derivatives as VEGFR-2 tyrosine kinase inhibitors, Bioorganic Chemistry, Volume 78, 2018, 393–405
11. Fan Q, Wang Y, Yan H*. An NMR and DFT investigation on the interconversion of 9-substituented-N6-hydrazone-8-azaadenine derivatives: proton migration or conformational isomerization?[J]. Structural Chemistry, 2018. 29(3), 871-879.
12. Wuji Sun, Qiangwen Fan, Hong Yan*, Manipulating [2+2] Photodimerization of 1,4-Dihydropyridines within γ-Cyclodextrin, Journal of Photochemistry and Photobiology A: Chemistry 359 (2018) 33–39
13. Qiangwen Fan, Hongbo Tan, Peng Li, Hong Yan,*Hetero-intermolecular [2+2] photoaddition of 1,4-dihydropyridines: A Combined Experimental and DFT Study, New Journal of Chemistry, 2018,42, 16795 – 16805
14. Qiangwen Fan, Runzhi Sun, Zhichang Zhao, Hong Yan*, Synthesis and theoretical study of pyrrole formiate derivatives through ring contraction of 1,4-dihydropyridines, Tetrahedron, 2018, 74,7457-7465
15. Zhong Q, Fan Q, Yan H*. Synthesis of 2,3-dihydropyrroles by photo rearrangement of Hantzsch 1, 4-dihydropyridines with high diastereoselectivity[J]. Tetrahedron Letters, 2017, 58(13): 1292-1295.
16. Hongxing Xin, Xiaohe Zhu, Hong Yan,* and Xiuqing Song，Revelation from the Reaction of 1,4-Diazabutadiene with Perchloric Acid: An Approach to the Synthesis of Imidazolium Perchlorates，J. Heterocyclic Chem., 2016, 53, 1363–1366.
17. Hong-bo Tan, Qi-di Zhong & Hong Yan*: Studies on the Photochemical Oxidation of N,N-Diacyl-1,4-dihydropyrazine Derivatives, Synthetic Communications, 2016, 46, 1-10.
18. Wuji Sun, Yangye Jiang, Hong Yan*, Synthesis and Photoreaction of 2-Amino-3-cyano-4-aryl-4H-pyrans, Aust. J. Chem. 2015, 68, 273–281.
19. Hongbo, Tan; Hongxing, Xin; Hong, Yan*. SYNTHESIS AND PHOTOCHEMICAL PROPERTIES OF 2,4,6,-TRIARYL-4H-1,4- OXAZINES. HETEROCYCLES, 2014, 89, 359-373.
20. Xin, H.; Sun, W.; Yan, H.*, Photochemical ring contraction of 1-aryl-1,4-dihydropyrazine to 1-aryl-1H-imidazoleJournal of Photochemistry and Photobiology A: Chemistry, 2013, 267, 49-54.
